Clemson Game Saturday: Clemson vs. Louisville odds and prediction for NCAA Week 10 game

The Clemson Tigers (5-3, 4-2) rebounded at home this past weekend with a 30-20 win over the Florida State Seminoles and now they’ll leave the friendly confines of Death Valley looking to build some potential momentum with a win on the road.

The Tigers will travel up to Kentucky to take on ACC Atlantic Division foe Louisville in a game that is a ‘must-win’ if Clemson wants to stay in the hunt to potentially win the division.

Louisville is coming into this one fresh off a 28-13 loss to NC State and the Cardinals currently possess a 4-4 overall record with a 2-3 record in conference.

Clemson at Louisville Odds Week 10

The Week 10 betting odds on WynnBET have Clemson listed as a slight 3.5-point favorite on the road. The Tigers covered the spread last week against Florida State (9.5 points) for the first time all season long.

The over/under total for this game is set at 46.5.

Clemson at Louisville Prediction Week 10

Since Week 1 when we were wrong about the Georgia game, we haven’t missed on a spread prediction for the Tigers. We’ve picked against the Tigers in every single matchup when it comes to the spread up until last week, where we picked Clemson to cover.

Last week, there was just a gut feeling that the Tigers would find a little more offense than what we had seen in previous weeks and they did, at least to a point, and finished the day with a backdoor cover on a last-second Barrett Carter scoop-n-score.

Coming into this one, there’s no doubt that Louisville can put up some points with QB Malik Cunningham at the point but– just like any offense that has faced the Tigers this season minus Pittsburgh– they’re going to have a tough time piecing together drives.

Clemson covers that small 3.5-point spread and finishes this one with a final score of something like 24-17.

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