Clemson Football: 10 Greatest Wins vs. South Carolina in History

Clemson Football: 10 Greatest Wins vs. South Carolina Gamecocks in History

COLUMBIA, SC - SEPTEMBER 22: D.J. Swearinger #36 of the South Carolina Gamecocks, who was suspended for the game, watches his team play against the Missouri Tigers at Williams-Brice Stadium on September 22, 2012 in Columbia, South Carolina. (Photo by Grant Halverson/Getty Images) /

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CLEMSON, SC – SEPTEMBER 01: The Clemson Tiger mascot does pushups after the Tigers scored a touchdown in the third quarter of their game against the Furman Paladins at Clemson Memorial Stadium on September 1, 2018 in Clemson, South Carolina. (Photo by Mike Comer/Getty Images) /

9. 1900: Largest Margin of Victory

Three years later, the John Heisman-led Clemson football team would march into Columbia and come away with a record-breaking performance.

The Tigers would defeat the Gamecocks 51-0.

To this day, that score remains the largest margin of victory ever in the rivalry. Clemson has had several big wins over South Carolina, but none bigger than that one more than 100 years ago.

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